An Evening with DocStars, hosted by The Cary Council, is on October 25 at UT Southwestern Medical Center. This signature event supports young UT Southwestern investigators working on promising early stage research, and we're sharing bios of the three finalist DocStars who were selected by UT Southwestern leadership and The Cary Council.

GreenbergDavid Greenberg, M.D. Addressing the global antibiotic resistance health crisis

Dr. Greenberg obtained his medical degree from Baylor College of Medicine, where he also completed a residency in internal medicine. While completing a subsequent fellowship in infectious disease from the National Institutes of Health (NIH), he was awarded the National Institute of Allergy and Infectious Disease Merit Award. Dr. Greenberg has also received numerous accolades for teaching including the UT System Regents’ Outstanding Teaching Award.

In his work, Dr. Greenberg aims to address the global antibiotic resistance health crisis. By using whole genome sequencing to read the DNA code for every gene within resistant bacteria, scientists hope to understand how those bacteria became resistant to certain antibiotics and determine which other antibiotics may still work. While it is now possible to cheaply and quickly sequence many entire genomes, complex computing is required to analyze the massive amounts of resulting data. To tackle this problem, Dr. Greenberg’s team is developing a sophisticated computer algorithm that will not only predict whether a strain of bacteria is resistant but also be used to discover new forms of resistance. Using samples from UT Southwestern clinics, they will focus on five of the most pressing bacterial strains to refine this algorithm. The goal of this project is to better understand the many different ways antibiotic resistance can occur at a molecular level and push the field forward in developing innovative diagnostics for infectious diseases.

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