The Cary Council’s 2nd annual signature event: An Evening with DocStars was held on UT Southwestern Medical Center’s West Campus on October 25, 2018. We thank everyone who helped make this year’s event a success! The generosity of our community made it possible for The Cary Council to award three $50,000 grants to the 2018 DocStars. Read more

E V E N T  C O – C H A I R S : Lana Constantine Amanda Eagle George

C H A I R M A N : Michael Kahn

Thank You to Our Sponsors

M E D I A  S P O N S O R

P L A T I N U M John Eagle Dealerships Eugene McDermott Foundation

G O L D Fluor Corporation Patricia Dedman Foundation Beth F. Kahn Family Sewell Automotive ZeoCap Partners and The Constantine Family

S I L V E R Grace Cook Goldman Sachs and Amber and Grafton Ifill Lisa and Matt Rose

B R O N Z E Kathy and Gene Bishop Nancy Collins Itzel and Nathan Crow Beverly and Larry Dale Amanda and Chris George Abby and Michael Gregory Linda and Mitch Hart Colleen Hayes Patty and James Huffines Barrell and Jacob Jones Katten, Muchin, Rosenman Kate Morris Gay and Bill Solomon Trinity Industries Lauren and Thomas Woolley

D O N A T I O N S  Anonymous Whitney and Jay Grogan Judith McGray McGray & McGray Land Surveyors Catherine and Will Rose Lizzie and Dan Routman

AlluriPrasanna Alluri, M.D., Ph.D. Building targeted therapies to overcome treatment-resistant breast cancer

Dr. Alluri earned his medical degree at the University of Minnesota Medical School and received a doctorate in chemical biology from UT Southwestern Medical Center. He then completed a research fellowship in translational oncology and a residency in radiation oncology at the University of Michigan Medical School, where he was also a chief resident. Dr. Alluri has received many recognitions for both his research contributions and clinical care, including the Conquer Cancer Foundation of ASCO/Breast Cancer Research Foundation Young Investigators Award in 2017.

Specialized in the treatment of breast cancer, Dr. Alluri hopes to address a primary obstacle all patients with metastatic breast cancer face—their tumors’ resistance to treatment. The goal of his project is to understand on a molecular level how tumors develop treatment resistance and to devise new targeted therapies to overcome resistance. To accomplish this, Dr. Alluri and his team will comprehensively analyze the genetic sequence of treatment-resistant patient tumors to understand how resistance works and identify new potential drug targets specific to each patient. By working with breast cancer cell lines, they have already identified a promising drug that inhibits growth of these treatment-resistant cells, providing clues into cellular pathways that may overcome resistance. As part of this project, they will further investigate this drug in mouse models of resistant tumors.

GreenbergDavid Greenberg, M.D. Addressing the global antibiotic resistance health crisis

Dr. Greenberg obtained his medical degree from Baylor College of Medicine, where he also completed a residency in internal medicine. While completing a subsequent fellowship in infectious disease from the National Institutes of Health (NIH), he was awarded the National Institute of Allergy and Infectious Disease Merit Award. Dr. Greenberg has also received numerous accolades for teaching including the UT System Regents’ Outstanding Teaching Award.

In his work, Dr. Greenberg aims to address the global antibiotic resistance health crisis. By using whole genome sequencing to read the DNA code for every gene within resistant bacteria, scientists hope to understand how those bacteria became resistant to certain antibiotics and determine which other antibiotics may still work. While it is now possible to cheaply and quickly sequence many entire genomes, complex computing is required to analyze the massive amounts of resulting data. To tackle this problem, Dr. Greenberg’s team is developing a sophisticated computer algorithm that will not only predict whether a strain of bacteria is resistant but also be used to discover new forms of resistance. Using samples from UT Southwestern clinics, they will focus on five of the most pressing bacterial strains to refine this algorithm. The goal of this project is to better understand the many different ways antibiotic resistance can occur at a molecular level and push the field forward in developing innovative diagnostics for infectious diseases.

TandonAnimesh (Aashoo) Tandon, M.D., M.S. Developing life-saving monitoring techniques for babies with congenital heart disease

During Dr. Tandon’s medical training at the University of Michigan Medical School, he performed a research fellowship at the National Institute of Neurological Disorders and Stroke/NIH through the Howard Hughes Medical Institute/NIH Research Scholars (Cloister) Program. He completed his pediatric residency and categorical pediatric cardiology fellowship at Cincinnati Children’s Hospital Medical Center. During fellowship, he earned a Masters in Clinical and Translational Research from the University of Cincinnati and then completed an advanced imaging fellowship at Children’s Healthcare of Atlanta/Emory University.

Dr. Tandon’s work focuses on infants diagnosed with congenital heart disease. For survival, these babies need three surgeries at ~1 week, at 4-6 months, and at ~2-5 years of age. The time between the first and second surgeries is particularly critical, as these infants are at increased risk of harmful health events and experience a death rate 20 times higher than healthy infants. Current monitoring techniques don’t provide doctors enough time to detect health deteriorations and better prevent these deaths. To do so, Dr. Tandon and his team propose that these infants wear special biosensors at home to continuously monitor data. The team will use advanced machine learning techniques to analyze massive amounts of collected data and to recognize patterns that precede dangerous health events. These patterns can then be used to predict future events, prompting medical intervention hours or days before the infant’s health becomes critical.

About The Cary Council

The Cary Council is dedicated to carrying on Dr. Edward H. Cary’s legacy to “inspire a great citizenship to greater deeds.”

In September 2015, Southwestern Medical Foundation and UT Southwestern launched The Cary Council, a group of emerging community leaders, whose mission is to support and strengthen the work of the Medical Center and Foundation. The Council was created to educate the next generation about the critical role medical research, education, and patient care plays in improving our health and making Dallas a world-class city. Learn more.

Funds raised from An Evening with DocStars support young UT Southwestern investigators working on promising early stage research. Philanthropy is vital in advancing early-stage research, which may be too nascent to qualify for other funding sources. Finalists will be chosen by UT Southwestern faculty and the recipient(s) will be selected by The Cary Council. Funds raised from last year’s inaugural event enabled The Cary Council to give three grants to young researchers to further their work.

The Cary Council Steering Committee

Michael Kahn, Chairman Nancy Collins Annika Cail Lana Constantine Grace Cook Pete Dale Andersen Fisher Amanda George Michael Gregory Grafton Ifill Jacob Jones Kate Morris Josie Sewell Amanda Dillard Shufeldt Ivy Wisco